This study aims to analyze medication adherence, quality of life, and non-motor symptoms in Parkinson’s disease patients in Azogues, Biblián, and Déleg. A descriptive and correlational approach was used, collecting data on various variables such as Age, Age at Diagnosis, Mobility, Daily Activity, Emotional Well-Being, Stigma, Social Support, Cognitive Status, Communication, Physical Discomfort, Medication Adherence, and Non-Motor Symptoms. The normality of variable distributions was assessed, and Pearson correlations were applied to examine their relationships. The results showed significant correlations between Age and other variables, such as Mobility, Daily Activity, and Emotional Well-Being. The relationship between Mobility and Daily Activity was extremely strong, and non-motor symptoms notably impacted quality of life, particularly Cognitive Status and Communication. The Gaussian graphical model revealed direct interactions between the variables. In conclusion, the research highlights how mobility, emotional well-being, and social support influence the quality of life of Parkinson’s patients, while non-motor symptoms negatively affect their overall well-being, suggesting key areas for intervention and improvement in the treatment of these patients.

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