Since 1961, the overlap between myasthenia gravis (MG) and systemic lupus erythematosus (SLE) has been increasingly recognized, with MG patients facing up to 13 times the risk of developing SLE, especially after thymectomy, predominantly in young women. Thymic B cells may play a role in MG and SLE, as shown in animal models. MG often coexists with family histories of autoimmune diseases, sharing genetic risk factors with SLE, as supported by genome-wide studies. Patients with both conditions also experience higher rates of other autoimmune diseases, suggesting a potential for broader autoimmunity. Early-onset MuSK-MG strengthens this observed connection.
autoimmunity
Encefalomielitis Aguda Diseminada: Reporte de un Caso con Afectación Selectiva de Tallo Cerebral.
Introduction: Acute Disseminated Encephalomyelitis (ADEM) is an autoimmune demyelinating disease of the central nervous system´s white matter; it usually has a monophasic course with an idiopathic cause or following infection or immunization processes.
Objective: This article has the purpose to present a clinical case with selective involvement of brainstem. We describe a 28 year old woman who developed ADEM. Her clinical presentation, neuroradiological findings and treatment are reported.
Conclusions: ADEM is an infrequent disease which can be fatal. MRI findings confirm the diagnosis and steroid therapy appears to be the most effective treatment, although the disease may spontaneously improve.
