México

Frecuencia de Casos Juveniles con Enfermedad de Huntington en Población Mexicana. Frequency Of Juvenile Huntington’s Disease In A Mexican Population.

Objective. The purpose of this study is to know the prevalence of juvenile cases in a sample of mexican subjects with confirmed Huntington Disease (HD).

Methods. Patients with clinical debut before 21 years of age were included who attended at movement disorders clinic of the National Institute of Neurology and Neurosurgery. The demographic and clinical information was obtained from the review of files.

Results. A total of 198 cases of patients diagnosed with HD were reviewed, of which 6.5% (n = .13) corresponded to juvenile forms. The mean age for the onset of symptoms was 17.8 ± 3.9 years. The mean score of the UHDRS-motor was 46.2 ± 17.4 points. The predominant motor symptom was chorea in (53.8%) of the cases. 84.6% of those affected presented at least one neuropsychiatric disorder.

Conclusion. It was detected that the dominant motor phenotype of these patients was chorea compared to the world reports until now, accordingly to that, our group of juvenile HD shows atypical motor clinical.

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Palabras clave: corea, enfermedad de Huntington, juvenil, México, Westphal,

Keywords: chorea, Huntington disease, juvenile, Mexico, Westphal.,

Información epidemiológica sobre la morbilidad hospitalaria en el Instituto Nacional de Neurología y Neurocirugía de la ciudad de México durante el período 2002-2007.

Hospital morbidity provides information for the strategic planning and implementation of health actions and programmes.

Objective: To determine the main causes of hospital morbidity, its distribution and behavior during the period 2000-2007 at the National Institute of Neurology and Neurosurgery in Mexico City (INNN).

Materials and Methods: An observational, transversal retrolective study was carried out. Data was collected from discharge notes and from the hospital database from the Epidemiology Department. The different rates of morbidity were calculated and their tendencies were determined for a period of six years.

Results: The main causes of morbidity were malignant encephalic tumors and benign tumors from other endocrine glands. However, a tendency to the increment of subarachnoid hemorrhage (p=0.03), cerebrovascular diseases (p=0.04) and benign brain tumors and from other parts of the central nervous system (p=0.01) was found.

Conclusions: Even though this is not a population study, the information obtained from one of the main training institutes and centers of the world and the largest in Latin America, is of great importance. It can be seen how, even though cerebrovascular diseases showed a tendency to increase, benign encephalic tumors occupy the main rates regarding morbidity.

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Palabras clave: Enfermedades Neurológicas, epidemiología, México, Morbilidad, Tasa, Tendencia, Variables,

Keywords: epidemiology, Mexico, morbidity, Neurological Diseases, rate, tendency, variables,

Características Clínicas del Temblor Esencial en México

We studied the clinical and genetic characteristics of 100 patients with definite diagnosis of essential tremor (ET), evaluated at the clinic of movement disorders of the National Institute of Neurology of Mexico. All patients hab laboratory (metabolic and endocrine tests), neurophysiologic studies, and neuroimaging studies to evaluate the presence of other potential causes of movement disorders. The study included 100 patients with definitive diagnosis of ET, 33 men and 67 women. The mean age at the time of diagnosis was 45,92 years (40.92 in men and 48.4 in women). Mean time from the onset of tremor to diagnosis was 10.60 years (13,71 in males and 9.07 in females). Family history of tremor was found in 56% of the patients. Patients with maternal inheritance had lower age of onset (35.61 years vs. 46.11 years, p<0.05). Five percent of the patients exhibited almost a total lack of capacity in writing and in fine and precise activities. This study showed that patients with ET inherited frim the mother exhibit a lower age of onset. A narrow relationship between the sex of the progenitor and ET probably exists, The torpid evolution of the tremor was noted in 5% of the cases, emphasizing the need for early therapy before deterioration becomes incapacitating.