Spinal cord injury continues to represent one of the greatest therapeutic challenges in neurology, not only due to the complexity of the initial damage but also because of persistent limitations in long-term functional recovery. Despite advances in rehabilitation, electrical stimulation, and pharmacological strategies, clinical outcomes remain modest. In this context, it is becoming increasingly clear that one of the main bottlenecks lies not solely in neuronal regeneration itself, but rather in the interface between neural tissue and the materials used for its repair or stimulation.



