Preventing Alzheimer’s disease has ceased to be a theoretical aspiration and has become a scientific, clinical, and social obligation. For decades, Alzheimer’s has been viewed with a mixture of resignation and fatalism, as if its onset were an inexorable part of aging. However, this narrative is no longer compatible with current knowledge. Today we know that a significant proportion of the risk of cognitive decline and dementia is linked to modifiable factors, and that intervening on these factors can delay or prevent a significant number of cases. This reality takes on even greater urgency when we consider that the number of people with dementia worldwide could rise from 57.4 million in 2019 to more than 150 million in 2050.

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