Publicación Oficial de la Sociedad Ecuatoriana de Neurología, de la Liga Ecuatoriana Contra la Epilepsia y de la Sociedad Iberoamericana de Enfermedad Cerebrovascular

Cognitive Dysfunction

 

Perfiles cognitivos-lingüísticos en personas mayores con Deterioro Cognitivo Leve, Demencia Vascular, Demencia con Cuerpos de Lewy y Enfermedad de Parkinson. Cognitive-linguistic profiles in older people with Mild Cognitive Impairment, Vascular Dementia, Dementia with Lewy Bodies and Parkinson’s Disease

Introduction: There is a wide heterogeneity of neuropsychological symptoms reported in pathological ageing. Current research has focused on patients with Alzheimer’s disease and frontotemporal dementia. However, still no detailed knowledge of the cognitive-linguistic profiles in patients whit Mild Cognitive Impairment (MCI) and other forms of dementia.

Objective: To characterize cognitive and linguistic profiles in older people with MCI, vascular dementia, Lewy body dementia, and Parkinson’s disease.

Methods: The present study followed the PRISMA guidelines and included studies from the PubMed, Scopus, and Web of Science databases, published between 2000 and 2020.

Results: 49 articles were included in this literature review for critical analysis. Older people with MCI, vascular dementia, Lewy body dementia, and Parkinson’s disease shows a significant decline in the following cognitive domains: memory, executive function, attention, and visuospatial/visuoconstructive skills. However, linguistic symptoms are also reported, especially the deficit in verbal fluency (semantic and phonological) and syntactic-grammatical and discursive skills.

Conclusion: This literature review characterized cognitive-linguistic profiles in older people with MCI, vascular dementia, Lewy body dementia, and Parkinson’s disease. These profiles could be helpful in clinical practice to improve early neuropsychological assessment processes and even determin e differential diagnoses between these clinical conditions.

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Ronquido, Eventos Respiratorios y Cardíacos Después de la Colocación de un Dispositivo de Avance Mandibular. Snoring, Respiratory And Cardiac Events After The Placement Of A Mandibular Advancement Device.

Objective: To compare snoring levels, respiratory and cardiac events before and after the placement of a new mandibular advancement device (MAD) designed for snoring control, placed as an option for the control of pathological mechanisms respiratory disorders that have been associated with cognitive dysfunction, excessive daytime sleepiness and as an aggravator of the development of Alzheimer’s and Parkinson’s.

Methodology: Study of a case series that considered 12 snoring adults initially identified with the Roncolab® App. A clinical history of sleep and initial (A) and final (D) polysomnography (PSG) was performed. A new design of intra-oral mandibular advancement device for snoring control was placed, which was reviewed every 20 days for two months. Neurophysiological, cardio-pulmonary and sleep parameters were analyzed. The statistical differences between the variables were established according to the distribution of the data with tests of t-student or Mann-Whitney U.

Results: The average snoring events according to PSG were (A: 198; D: 260) with p> 0.05; according to Roncolab® (A: 73.6; D: 22.6) with a p <0.05. There were no differences between the oximetry averages (A: 0.84; D: 0.83) or heart rate (A: 65; D: 66.9).

Conclusions: There was no statistically significant difference in respiratory, cardiac events, oximetry nor apnea episodes according to PSG, after the placement of the manufactured DAM. Roncolab® registered a significant decrease in snoring events.

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Deterioro Cognitivo y Demencias en Adultos con Trastorno del Espectro Autista. Cognitive Impairment and Dementia in Adults with Autism Spectrum Disorder.

Autism Spectrum Disorder (ASD) has been studied mainly in children. However, currently, 1/68 adults live with this neurodevelopmental disorder. ASD in adulthood shows suggestive symptoms of cognitive impairment, quickly compromising various cognitive functions. Cognitive impairment and behavioral disorders help to develop neurodegenerative diseases such as Frontotemporal dementia (FTD) and Alzheimer’s Disease (AD) in people with ASD during adulthood, which affects activities of daily living (ADL). The objective of this systematic review is to investigate the progression of ASD to cognitive impairment and dementia in adulthood. The methodology included the qualitative analysis of studies published in the years 2000 and 2020, exclusively in english. Results reveal that adults with ASD develop early cognitive impairment and dementia according to the general population, mainly affecting cognitive functions such as memory and executive functions. In conclusion, moderate to a profound degree of intellectual disability, as well as reductions in white matter, seems to be precursors for the development of cognitive impairment and dementia in adults with ASD.

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