Publicación Oficial de la Sociedad Ecuatoriana de Neurología, de la Liga Ecuatoriana Contra la Epilepsia y de la Sociedad Iberoamericana de Enfermedad Cerebrovascular

Chronic stress

 

Influencia del Estrés Crónico y de la Masticación Sobre el Dolor. Influence Of Chronic Stress And Chewing Over Pain.

Introduction: Chronic stress and mastication affect the response to pain; however, there is little knowledge about the relationship between these variables.

Objective: Determine the influence of chronic stress and mastication on the response to pain.

Methods: thirty-two 8-week-old male Balb/c mice were used. The sample was divided into 4 equal groups: Group N: normal mastication without stress; Group NE: Normal chewing + stress, Group D: deficient chewing without stress and Group DE: Poor chewing + stress. The response to the painful stimulus was evaluated through the tail withdrawal assay due to a thermal stimulus.

Results: By comparing the 4 experimental groups to the fourth and the eighth week through the ANOVA test yielded a value of p = 0.982 and p = 0.176; respectively. By applying the ‘t’ student, within each group, in comparison of the variation of the pain response between the fourth and eighth week, the values ​​of p = 0.52; p = 0.17; p = 0.84 and p = 0.069 were obtained for the group N, NE, D and DE respectively.

Conclusion: Chronic stress and mastication do not modify the response to pain in albino Balb/c mice.

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Neurobiología del Estrés Agudo y Crónico: Su Efecto en el Eje Hipotálamo-Hipófisis-Adrenal y la Memoria.

The presently available data about stress and its effects is too broad. That’s why this paper will focus on the effect of stress hormones in some brain areas, like limbic structures and the hypothalamo-pituitary-adrenal axis. In this way we will discuss how repetitive stress can change those areas, mainly by the effect on its two types of nuclear receptors, changing the basal activity of the amygdala, hippocampus and the medial prefrontal cortex, resulting in an increased hypothalamo-pituitaryadrenal axis function and impairing cognitive functions like memory. However, the exact mechanism by which these effects are produced is poorly understood. That is why one of the challenges for future research is to link the cellular changes with its behavioral effects in order to understand how it works in a living organism.

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