A clinical case of PD is provided in which we analyze the autonomic involvement in response to pain, using various neurophysiological parameters. After the neurophysiological examination of pain thresholds (hand grip), this patient with 13 years history of Parkinson’s disease, showed a peripheral decrease that made the measurement of blood pressure not very stable. Sympathetic activity and nociceptive sensitivity were diminished, expressing the postganglionar noradrenergic myocardial denervation as it is widely known in parkinsonian patients. It is important to have in mind the autonomic nervous system involvement in Parkinson’s disease.
dolor
Influencia del Estrés Crónico y de la Masticación Sobre el Dolor. Influence Of Chronic Stress And Chewing Over Pain.
Introduction: Chronic stress and mastication affect the response to pain; however, there is little knowledge about the relationship between these variables.
Objective: Determine the influence of chronic stress and mastication on the response to pain.
Methods: thirty-two 8-week-old male Balb/c mice were used. The sample was divided into 4 equal groups: Group N: normal mastication without stress; Group NE: Normal chewing + stress, Group D: deficient chewing without stress and Group DE: Poor chewing + stress. The response to the painful stimulus was evaluated through the tail withdrawal assay due to a thermal stimulus.
Results: By comparing the 4 experimental groups to the fourth and the eighth week through the ANOVA test yielded a value of p = 0.982 and p = 0.176; respectively. By applying the ‘t’ student, within each group, in comparison of the variation of the pain response between the fourth and eighth week, the values of p = 0.52; p = 0.17; p = 0.84 and p = 0.069 were obtained for the group N, NE, D and DE respectively.
Conclusion: Chronic stress and mastication do not modify the response to pain in albino Balb/c mice.
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Palabras clave: dolor,
Estrés crónico,
masticación,
neurociencias experimentales,
respuesta dolorosa,
Dolor en Síndrome de Guillain Barré: Una Manifestación Subestimada. Pain In Guillain Barré Syndrome: An Underestimated Manifestation.
Guillain-Barré syndrome is an acute demyelinating polyneuropathy that presents clinically with muscular weakness and autonomic disorders in its typical form, while the sensory symptoms usually go unnoticed.
We describe the clinical history of a male patient with acute flaccid quadriparesis and sensory disorders such as paresthesia and allodynia that hinder diagnosis within the initial approach.
Complete diagnostic work up confirmed the presence of Guillain-Barré syndrome. Although the sensory symptoms confused the diagnosis during admission, it is important to highlight that pain is a frequent manifestation of this disorder, being underestimated in many patients.
