Publicación Oficial de la Sociedad Ecuatoriana de Neurología, de la Liga Ecuatoriana Contra la Epilepsia y de la Sociedad Iberoamericana de Enfermedad Cerebrovascular

Pharmacoepidemiology

 

Prescription Patterns Of Antimigraine Drugs. Patrones de Utilización de Antimigrañosos.

Introduction: The objective was to determine the prescription patterns of antimigraine drugs in a Colombian population.

Methods: A cross-sectional study of a population database that recorded all patients diagnosed with migraine and the drugs used for crisis and prophylaxis treatment for at least three months during 2018. Multivariate analysis was performed to identify variables associated with the use of prophylaxis.

Results: A total of 5973 patients diagnosed with migraine were identified, with a mean age of 37.7±14.5 years and female predominance (81.3%). The most common diagnosis was migraine without aura (36.9%), followed by migraine with aura (28.4%). Overall, 7.3% of patients were treated by neurologists and 92.8% by general practitioners, and 85.4% (n=5101) received treatment for acute episodes. Nonsteroidal anti-inflammatory drugs (52.1%) were the most prescribed drugs, followed by ergotamine (42.1%). The 46.3% of patients were receiving prophylactic therapy. Women older than 35 years and patients treated by neurologists were more likely to receive prophylactic therapy.

Conclusions: The use of medications for acute migraine management prevailed, with a very low proportion of triptans. Despite the significant undesirable effects, ergotamine continues to be used frequently. Physicians should evaluate the need for prophylaxis, focusing on finding an effective therapy that reduces disabilities.

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Profilaxis en la Migraña: Descripción de la Prescripción en un Primer Nivel de Colombia. Migraine Prophylaxis: Description Of The Prescription In A First Level Of Colombia

Introduction: Migraine is a prevalent disease, crisis can be prevented with medication for not less than 6 months.

Objective: To identify the drugs used for the prophylactic treatment of migraine, inappropriate prescriptions and associated variables.

Materials and methods. Cross-sectional study, in patients of legal age, diagnosed with migraine and prescribed with prophylactic medications. Sociodemographic, comedication, comorbidities and drugs variables were included. Univariate, bivariate and binary logistic regression analysis was performed. Inappropriate prescription was defined by the formulation of drugs without evidence of effectiveness for prophylaxis or by the use of drugs at doses or subtherapeutic times.

Results: 241 patients were included, 87.1% were women. 87.6% of patients received effective drugs, 10.8% probably effective, 2.5% possibly effective and 10.4% drugs without evidence. Propranolol was the most commonly used drug for prophylaxis, on average for 69.1±57.2 days, followed by valproic acid (53.2±55.3 days) and amitriptyline (45.7±39.6 days). 99.6% of patients presented an inappropriate prescription.

Conclusions: A high inadequate prescription of medications for the prophylactic treatment of migraine was identified due to not complying with the recommended dose and duration, as well as an important use of drugs without evidence.

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