Migraine is a pathology predominant in women; being 2 to 3 times more prevalent than in men. It’s frequently associated with physiological changes in ovarian steroids levels, during the menstrual cycle and in menopause. Despite this strong association, few studies have examined the mechanism through the ovarian steroids influence the neural system in migraines. Clinical data demonstrate that high levels of estrogens increase the probability of having migraine. Paradoxically the sudden descent of estrogens during menstruation increases the probability of having a migraine attack.