Publicación Oficial de la Sociedad Ecuatoriana de Neurología, de la Liga Ecuatoriana Contra la Epilepsia y de la Sociedad Iberoamericana de Enfermedad Cerebrovascular

Middle cerebral artery occlusion

 

External capsule infarct related to occlusion of the middle cerebral artery. Infarto en la cápsula externa relacionado con oclusión de la arteria cerebral media.

The external capsule is a band of longitudinal fibers (white matter) limited by two deep gray matter structures, the putamen medially and the claustrum laterally (Figure 1).

This structure is mainly composed of axons that connect different areas of the cerebral cortex with the tegmentum (corticotegmental fibers).

Ischemic strokes confined to the external capsule are extremely rare, representing 0.3% of patients enrolled in a large hospital-based ischemic stroke registry.

External capsule infarcts may be related to different pathogenic mechanisms, including large artery disease, cardiogenic brain embolism, sporadic cerebral small vessel disease, or to a combination of them.

In addition, external capsule infarcts have been typically reported in a hereditary form of cerebral small vessel disease known as CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).

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Comparison of hemorheology and plasma contents of TXB2, 6-Keto-PGF1 alpha in model rats with three kinds of cerebral ischemia.

Objective: To compare changing features of hemorheological, TXB2 and 6-keto-PGF1 alpha in plasma in three kinds of model rats with cerebral ischemia.

Materials and Methods: 128 adult male Sprague-Dawley rats were randomly divided into four groups: a middle cerebral artery occlusion with intraluminal thread group (MCAO-group), a bilateral common carotid artery ligation group (BCCA-group), a unilateral common carotid artery ligation group (UCCA-group) and a normal control group (NC-group). Blood for hemorheological testing of all rats was taken from abdominal aorta 24h following cerebral ischemia and hemorheological index was determined. Plasma contents of TXB2 and 6-keto-PGF1 alpha were detected by radio-immunity.

Results: The whole blood viscosity value, plasma viscosity value, and hematocrit were higher in MCAO-group among three model groups, followed by BCCA-group and UCCA-group. The deformity index of RBC in MCAO-group was significantly lower than that in normal-group. There were significant differences for plasma contents of TXB2 and 6-keto-PGF1 alpha among the three model groups and the normal group. There were significant differences for plasma level of 6-Keto-PGF1a, TXB2 between MCAO-group and the normal group, but no difference among the three model groups(p>0.05).

Conclusion: MCAO was the greatest in contribute to changes of hemorheology and plasma contents of TXB2, 6-keto-PGF1 alpha among three rat models with cerebral ischemia.

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