A seizure-free 74-year-old woman had a single calcified cysticercus (Figure 1), and normal hippocampi (Figure 2, upper panel). Neuroimaging exams were practiced for a study aimed to assess the association between neurocysticercosis and hippocampal atrophy (HA).1 Seven years later, a control MRI showed bilateral HA (Figure 2, lower panel). The patient remained seizure-free during the observation period.
The association between calcified cysticercus and HA in seizure-free individuals has been recognized.2 It has been postulated that repetitive episodes of inflammation from antigens released to the brain parenchyma from calcifications are responsible for remote HA. However, HA progression in these patients has not been reported. This case underscores the need of early treatment with bisphosphonates to reverse the calcification process in the brain, reducing the risk of progressive HA.3
